dc.contributor.author | Tabrizi, Leila | |
dc.contributor.author | McArdle, Patrick | |
dc.contributor.author | Erxleben, Andrea | |
dc.contributor.author | Chiniforoshan, Hossein | |
dc.date.accessioned | 2017-05-24T13:08:58Z | |
dc.date.issued | 2015-09-25 | |
dc.identifier.citation | Tabrizi, Leila, McArdle, Patrick, Erxleben, Andrea, & Chiniforoshan, Hossein. (2015). Cytotoxicity and antimicrobial activity of triorganotin(IV) complexes of phenylcyanamide prepared by sonochemical synthesis. Inorganica Chimica Acta, 438, 94-104. doi: https://doi.org/10.1016/j.ica.2015.09.011 | en_IE |
dc.identifier.issn | 0020-1693 | |
dc.identifier.uri | http://hdl.handle.net/10379/6543 | |
dc.description.abstract | This article describes the synthesis and characterization of novel triorganotin(IV) complexes and their potential medicinal applications. Triorganotin(IV) complexes with formulas [(SnMe3)(2)(mu-bp)(H2O)(2)], 1, and [(SnMe3)(4-NO(2)pcyd)], 2, (Me: methyl, bpH(2): 4,4'-dicyanamidobiphenyl and 4-NO(2)pcyd: 4-nitrophenylcyanamide) have been synthesized via a sonochemical process and characterized using multinuclear NMR (H-1, C-13 and Sn-119), Mossbauer spectroscopy, elemental analysis, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Compounds 1 and 2 were evaluated for their DNA/protein binding with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA), respectively. The in vitro cytotoxicity of 1 and 2 was examined against A549, Du145, HeLa and MCF-7 cancer cell lines. For 1, a promising growth inhibitory effect against HeLa cells was observed that is slightly higher than that of cisplatin. Moreover, the antimicrobial activity of 1 and 2 against different strains of pathogenic bacteria and fungi were tested. The free radical scavenging ability (OH, NO) of 1 and 2 was assessed. (C) 2015 Elsevier B.V. All rights reserved. | en_IE |
dc.description.sponsorship | We are grateful for the financial support from the Department of Chemistry, Isfahan University Of Technology (IUT). | en_IE |
dc.format | application/pdf | en_IE |
dc.language.iso | en | en_IE |
dc.publisher | Elsevier | en_IE |
dc.relation.ispartof | Inorganica Chimica Acta | en |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | Triorganotin phenylcyanamide | en_IE |
dc.subject | DNA binding | en_IE |
dc.subject | BSA binding | en_IE |
dc.subject | Antioxidant activity | en_IE |
dc.subject | Cytotoxicity | en_IE |
dc.subject | Bovine serum albumin | en_IE |
dc.subject | Bovine serum-albumin | en_IE |
dc.subject | In-vitro cytotoxicity | en_IE |
dc.subject | Tridentate schiff-base | en_IE |
dc.subject | DNA-binding properties | en_IE |
dc.subject | SN-119 nmr-spectra | en_IE |
dc.subject | X-ray-diffraction | en_IE |
dc.subject | Calf thymus DNA | en_IE |
dc.subject | State C-13 NMR | en_IE |
dc.subject | SN-ME angle | en_IE |
dc.subject | Crystal -structure | en_IE |
dc.title | Cytotoxicity and antimicrobial activity of triorganotin(IV) complexes of phenylcyanamide prepared by sonochemical synthesis | en_IE |
dc.type | Article | en_IE |
dc.date.updated | 2017-05-18T12:51:24Z | |
dc.identifier.doi | 10.1016/j.ica.2015.09.011 | |
dc.local.publishedsource | https://doi.org/10.1016/j.ica.2015.09.011 | en_IE |
dc.description.peer-reviewed | peer-reviewed | |
dc.contributor.funder | |~| | |
dc.description.embargo | 2017-09-25 | |
dc.internal.rssid | 10170602 | |
dc.local.contact | Andrea Erxleben, School Of Chemistry, Room 150, Arts/Science Building, Nui Galway. 2483 Email: andrea.erxleben@nuigalway.ie | |
dc.local.copyrightchecked | No | |
dc.local.version | ACCEPTED | |
nui.item.downloads | 446 | |