Browsing National Centre for Biomedical Engineering Science by Author "Smith, Terry J."
Now showing items 1-6 of 6
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Alignment-free clustering of transcription factor binding motifs using a genetic-k-medoids approach
Ó Broin, Pilib; Smith, Terry J.; Golden, Aaron (BioMed Central, 2015-01-28)Background: Familial binding profiles (FBPs) represent the average binding specificity for a group of structurally related DNA-binding proteins. The construction of such profiles allows the classification of novel motifs ... -
Development of a rapid recombinase polymerase amplification assay for the detection of Streptococcus pneumoniae in whole blood
Clancy, Eoin; Higgins, Owen; Boo, Teck Wee; Cormican, Martin; Barry, Thomas; Smith, Terry J. (BioMed Central, 2015-10-29)Background: Streptococcus pneumoniae is an important cause of microbial disease in humans. The introduction of multivalent vaccines has coincided with a dramatic decrease in the number of pneumococcal-related deaths. In ... -
Effects of combined progesterone and 17 beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells
Chandran, Sreenath; Cairns, Michael T.; O'Brien, Margaret; O'Connell, Enda; Mashayekhi, Kaveh; Smith, Terry J. (American Physiological Society, 2016-01-01)A transcriptomic analysis of cultured human uterine smooth muscle cells (hUtSMCs) was performed to examine gene expression profiles in smooth muscle in an environment containing the two major steroid hormones that regulate ... -
Isolation and characterization of the bovine Stearoyl-CoAdesaturase promoter and analysis of polymorphisms in the promoter region in dairy cows
Keating, Aileen F.; Murphy, John J.; Smith, Terry J.; Cairns, Michael T. (Springer, 2005-03)Conjugated linoleic acid (CLA) in milk arises through microbial biohydrogenation of dietary polyunsaturated fatty acids (PUFA) in the rumen, and by the action of mammary Stearoyl-CoA desaturase (Scd). A large variation ... -
A note on the evaluation of a beta-casein variant in bovine breeds by allele-specific PCR and relevance to beta-casomorphin
Keating, Aileen F.; Smith, Terry J.; Cairns, Michael T. (Teagasc; De Gruyter Open, 2008)Two genetic variants of the bovine beta-casein gene (A(1) and B) encode a histidine residue at codon 67, resulting in potential liberation of a bioactive peptide, beta-casomorphin, upon digestion. An allele-specific PCR ... -
A single nucleotide polymorphism in the bovine beta-casein promoter region across different bovine breeds
Keating, Aileen F.; Smith, Terry J.; Cairns, Michael T. (Cambridge Journals, 2006-02-14)The bovine β-casein (CSN2) gene has been shown to span a region of 8·5 kb, containing nine exons and eight intervening introns (Bonsing et al. 1988; Martin et al. 2002). The exons range in size from 24 to 498 bp; the ...