Chemical investigation of alkaloids from two haplosclerida sponges collected in Papua New Guinea
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Date
2023-08-21Author
Besliu, Denis
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Abstract
The phylum Porifera contributes immensely to the repertoire of marine natural
products amassed to date. Regions of the Pacific Ocean where chemical diversity
was not previously assessed were analysed and samples of various organisms
including sponges were collected during the Tara Pacific expedition in 2016. Two
sponges of the family Haplosclerida were selected for chemical investigation due
to their chemical profile where mass spectrometry analysis showed the presence
of alkaloids. Marine alkaloids are known to possess high bioactivity against
various diseases. The objectives of this Masters are to isolate alkaloids from these
sponges, elucidate their structures using NMR and test their bioactivity in terms of
cytotoxicity and antioxidant activity. This investigation lead to the discovery of 4
known compounds, 1 new compound and left us with highly interesting NMR
results for 2 further compounds.