Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
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2016-10-13Author
Guadalupe, Tulio
Mathias, Samuel R.
vanErp, Theo G. M.
Whelan, Christopher D.
Zwiers, Marcel P.
Abe, Yoshinari
Abramovic, Lucija
Agartz, Ingrid
Andreassen, Ole A.
Arias-Vásquez, Alejandro
Aribisala, Benjamin S.
Armstrong, Nicola J.
Arolt, Volker
Artiges, Eric
Ayesa-Arriola, Rosa
Baboyan, Vatche G.
Banaschewski, Tobias
Barker, Gareth
Bastin, Mark E.
Baune, Bernhard T.
Blangero, John
Bokde, Arun L.W.
Boedhoe, Premika S.W.
Bose, Anushree
Brem, Silvia
Brodaty, Henry
Bromberg, Uli
Brooks, Samantha
Büchel, Christian
Buitelaar, Jan
Calhoun, Vince D.
Cannon, Dara M.
Cattrell, Anna
Cheng, Yuqi
Conrod, Patricia J.
Conzelmann, Annette
Corvin, Aiden
Crespo-Facorro, Benedicto
Crivello, Fabrice
Dannlowski, Udo
de Zubicaray, Greig I.
de Zwarte, Sonja M.C.
Deary, Ian J.
Desrivières, Sylvane
Doan, Nhat Trung
Donohoe, Gary
Dørum, Erlend S.
Ehrlich, Stefan
Espeseth, Thomas
Fernández, Guillén
Flor, Herta
Fouche, Jean-Paul
Frouin, Vincent
Fukunaga, Masaki
Gallinat, Jürgen
Garavan, Hugh
Gill, Michael
Suarez, Andrea Gonzalez
Gowland, Penny
Grabe, Hans J.
Grotegerd, Dominik
Gruber, Oliver
Hagenaars, Saskia
Hashimoto, Ryota
Hauser, Tobias U.
Heinz, Andreas
Hibar, Derrek P.
Hoekstra, Pieter J.
Hoogman, Martine
Howells, Fleur M.
Hu, Hao
Hulshoff Pol, Hilleke E.
Huyser, Chaim
Ittermann, Bernd
Jahanshad, Neda
Jönsson, Erik G.
Jurk, Sarah
Kahn, Rene S.
Kelly, Sinead
Kraemer, Bernd
Kugel, Harald
Kwon, Jun Soo
Lemaitre, Herve
Lesch, Klaus-Peter
Lochner, Christine
Luciano, Michelle
Marquand, Andre F.
Martin, Nicholas G.
Martínez-Zalacaín, Ignacio
Martinot, Jean-Luc
Mataix-Cols, David
Mather, Karen
McDonald, Colm
McMahon, Katie L.
Medland, Sarah E.
Menchón, José M.
Morris, Derek W.
Mothersill, Omar
Maniega, Susana Munoz
Mwangi, Benson
Nakamae, Takashi
Nakao, Tomohiro
Narayanaswaamy, Janardhanan C.
Nees, Frauke
Nordvik, Jan E.
Onnink, A. Marten H.
Opel, Nils
Ophoff, Roel
Paillère Martinot, Marie-Laure
Papadopoulos Orfanos, Dimitri
Pauli, Paul
Paus, Tomáš
Poustka, Luise
Reddy, Janardhan YC.
Renteria, Miguel E.
Roiz-Santiáñez, Roberto
Roos, Annerine
Royle, Natalie A.
Sachdev, Perminder
Sánchez-Juan, Pascual
Schmaal, Lianne
Schumann, Gunter
Shumskaya, Elena
Smolka, Michael N.
Soares, Jair C.
Soriano-Mas, Carles
Stein, Dan J.
Strike, Lachlan T.
Toro, Roberto
Turner, Jessica A.
Tzourio-Mazoyer, Nathalie
Uhlmann, Anne
Hernández, Maria Valdés
van den Heuvel, Odile A.
van der Meer, Dennis
van Haren, Neeltje E.M .
Veltman, Dick J.
Venkatasubramanian, Ganesan
Vetter, Nora C.
Vuletic, Daniella
Walitza, Susanne
Walter, Henrik
Walton, Esther
Wang, Zhen
Wardlaw, Joanna
Wen, Wei
Westlye, Lars T.
Whelan, Robert
Wittfeld, Katharina
Wolfers, Thomas
Wright, Margaret J.
Xu, Jian
Xu, Xiufeng
Yun, Je-Yeon
Zhao, JingJing
Franke, Barbara
Thompson, Paul M.
Glahn, David C.
Mazoyer, Bernard
Fisher, Simon E.
Francks, Clyde
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Guadalupe, Tulio; Mathias, Samuel R. vanErp, Theo G. M.; Whelan, Christopher D.; Zwiers, Marcel P.; Abe, Yoshinari; Abramovic, Lucija; Agartz, Ingrid; Andreassen, Ole A.; Arias-Vásquez, Alejandro; Aribisala, Benjamin S.; Armstrong, Nicola J.; Arolt, Volker; Artiges, Eric; Ayesa-Arriola, Rosa; Baboyan, Vatche G.; Banaschewski, Tobias; Barker, Gareth; Bastin, Mark E.; Baune, Bernhard T.; Blangero, John; Bokde, Arun L.W.; Boedhoe, Premika S.W.; Bose, Anushree; Brem, Silvia; Brodaty, Henry; Bromberg, Uli; Brooks, Samantha; Büchel, Christian; Buitelaar, Jan; Calhoun, Vince D.; Cannon, Dara M.; Cattrell, Anna; Cheng, Yuqi; Conrod, Patricia J.; Conzelmann, Annette; Corvin, Aiden; Crespo-Facorro, Benedicto; Crivello, Fabrice; Dannlowski, Udo; de Zubicaray, Greig I.; de Zwarte, Sonja M.C.; Deary, Ian J.; Desrivières, Sylvane; Doan, Nhat Trung; Donohoe, Gary; Dørum, Erlend S.; Ehrlich, Stefan; Espeseth, Thomas; Fernández, Guillén; Flor, Herta; Fouche, Jean-Paul; Frouin, Vincent; Fukunaga, Masaki; Gallinat, Jürgen; Garavan, Hugh; Gill, Michael; Suarez, Andrea Gonzalez; Gowland, Penny; Grabe, Hans J.; Grotegerd, Dominik; Gruber, Oliver; Hagenaars, Saskia; Hashimoto, Ryota; Hauser, Tobias U.; Heinz, Andreas; Hibar, Derrek P.; Hoekstra, Pieter J.; Hoogman, Martine; Howells, Fleur M.; Hu, Hao; Hulshoff Pol, Hilleke E.; Huyser, Chaim; Ittermann, Bernd; Jahanshad, Neda; Jönsson, Erik G.; Jurk, Sarah; Kahn, Rene S.; Kelly, Sinead; Kraemer, Bernd; Kugel, Harald; Kwon, Jun Soo; Lemaitre, Herve; Lesch, Klaus-Peter; Lochner, Christine; Luciano, Michelle; Marquand, Andre F.; Martin, Nicholas G.; Martínez-Zalacaín, Ignacio; Martinot, Jean-Luc; Mataix-Cols, David; Mather, Karen; McDonald, Colm; McMahon, Katie L.; Medland, Sarah E.; Menchón, José M.; Morris, Derek W.; Mothersill, Omar; Maniega, Susana Munoz; Mwangi, Benson; Nakamae, Takashi; Nakao, Tomohiro; Narayanaswaamy, Janardhanan C.; Nees, Frauke; Nordvik, Jan E.; Onnink, A. Marten H.; Opel, Nils; Ophoff, Roel; Paillère Martinot, Marie-Laure; Papadopoulos Orfanos, Dimitri; Pauli, Paul; Paus, Tomáš; Poustka, Luise; Reddy, Janardhan YC.; Renteria, Miguel E.; Roiz-Santiáñez, Roberto; Roos, Annerine; Royle, Natalie A.; Sachdev, Perminder; Sánchez-Juan, Pascual; Schmaal, Lianne; Schumann, Gunter; Shumskaya, Elena; Smolka, Michael N.; Soares, Jair C.; Soriano-Mas, Carles; Stein, Dan J.; Strike, Lachlan T.; Toro, Roberto; Turner, Jessica A.; Tzourio-Mazoyer, Nathalie; Uhlmann, Anne; Hernández, Maria Valdés; van den Heuvel, Odile A.; van der Meer, Dennis; van Haren, Neeltje E.M .; Veltman, Dick J.; Venkatasubramanian, Ganesan; Vetter, Nora C.; Vuletic, Daniella; Walitza, Susanne; Walter, Henrik; Walton, Esther; Wang, Zhen; Wardlaw, Joanna; Wen, Wei; Westlye, Lars T.; Whelan, Robert; Wittfeld, Katharina; Wolfers, Thomas; Wright, Margaret J.; Xu, Jian; Xu, Xiufeng; Yun, Je-Yeon; Zhao, JingJing; Franke, Barbara; Thompson, Paul M.; Glahn, David C.; Mazoyer, Bernard; Fisher, Simon E.; Francks, Clyde (2016). Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging and Behavior 11 (5), 1497-1514
Published Version
Abstract
The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 dataset worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.