Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
View/ Open
Full Text
Date
2015-02-05Author
Bowes, John
Budu-Aggrey, Ashley
Huffmeier, Ulrike
Uebe, Steffen
Steel, Kathryn
Hebert, Harry L.
Wallace, Chris
Massey, Jonathan
Bruce, Ian N.
Bluett, James
Feletar, Marie
Morgan, Ann W.
Marzo-Ortega, Helena
Donohoe, Gary
Morris, Derek W.
Helliwell, Philip
Ryan, Anthony W.
Kane, David
Warren, Richard B.
Korendowych, Eleanor
Alenius, Gerd-Marie
Giardina, Emiliano
Packham, Jonathan
McManus, Ross
FitzGerald, Oliver
McHugh, Neil
Brown, Matthew A.
Ho, Pauline
Behrens, Frank
Burkhardt, Harald
Reis, Andre
Barton, Anne
Metadata
Show full item recordUsage
This item's downloads: 0 (view details)
Cited 103 times in Scopus (view citations)
Recommended Citation
Bowes, John; Budu-Aggrey, Ashley; Huffmeier, Ulrike; Uebe, Steffen; Steel, Kathryn; Hebert, Harry L. Wallace, Chris; Massey, Jonathan; Bruce, Ian N.; Bluett, James; Feletar, Marie; Morgan, Ann W.; Marzo-Ortega, Helena; Donohoe, Gary; Morris, Derek W.; Helliwell, Philip; Ryan, Anthony W.; Kane, David; Warren, Richard B.; Korendowych, Eleanor; Alenius, Gerd-Marie; Giardina, Emiliano; Packham, Jonathan; McManus, Ross; FitzGerald, Oliver; McHugh, Neil; Brown, Matthew A.; Ho, Pauline; Behrens, Frank; Burkhardt, Harald; Reis, Andre; Barton, Anne (2015). Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis. Nature Communications 6 ,
Published Version
Abstract
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared with psoriasis. Here, we present results from a case-control association study on 1,962 PsA patients and 8,923 controls using the Immunochip genotyping array. We identify eight loci passing genome-wide significance, secondary independent effects at three loci and a distinct PsA-specific variant at the IL23R locus. We report two novel loci and evidence of a novel PsA-specific association at chromosome 5q31. Imputation of classical HLA alleles, amino acids and SNPs across the MHC region highlights three independent associations to class I genes. Finally, we find an enrichment of associated variants to markers of open chromatin in CD8(+) memory primary T cells. This study identifies key insights into the genetics of PsA that could begin to explain fundamental differences between psoriasis and PsA.